NLRP3 Degrader

NLRP3 Degrader (1):

Cat. No.	Product Name	Effect	Purity

HY-162588

MC-ND-18	Degrader
MC-ND-18 is an ATTEC degrader that degrades NLRP3 via the Autophagy pathway, with a DC₅₀ of 125.5 nM in THP-1 cells. MC-ND-18 exhibits anti-inflammatory activity in a DSS-induced mouse model of colitis. MC-ND-18 can be used for research on inflammatory bowel disease. MC-ND-18 consists of an NLRP3 inhibitor (HY-156121), a linker (HY-W018745), and an LC3 ligand.

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